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Regular monitoring of side effects is essential

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Consequently, the present review aims to more comprehensively summarize the current understanding of the involvement of GLP-1RAs across distinct categories of pain, elucidate their mechanisms of action, and shed light on the future direction of clinical investigations by incorporating findings from newly published studies on GLP-1RAs in pain modalities

These are promising results, but the studys authors note that more research is needed, and clinicians must also consider potential adverse effects, evaluate the cost-effectiveness of these medications for each patient, and closely monitor for any improvement or worsening of eating disorders and related side effects. That hesitation is shared by the National Eating Disorder Association (NEDA), who published an opinion paper on GLP-1s and eating disorders in 2024, stating: While there is some evidence that GLP-1s can decrease the number of binge eating episodes for those with BED, little is known about the long term physical and psychological impact on those with eating disorders. How GLP-1s could also fuel eating disorders The same mechanisms that make these medications helpful for some could make them harmful for others